Senior Expert Science and Technology - Oligonucleotide

Key Responsibilities

• Responsible to develop and validate robust analytical methodologies applied to innovative Oligonucleotides therapeutics. Strong experience in various chromatography techniques is a pre-requisite. Experience in mass spectrometry applied to biological molecules would be an asset.
• Responsible to design, plan, conduct, interpret and report analytical activities for DS and/or DP applying state of the art analytical science and technologies (e.g., analytical method developments/validations/transfers/stability/release testing, formulation development analytics etc.) according to the agreed timelines and appropriate quality standards.
• Contribute to the planning and execution of experiments in the lab for assigned projects (for e.g., scheduling of activities in the lab, experimental overview, data evaluation).
• Author analytical documents supporting the analytical and the global project strategies based on project phase. Contribute to strategic decisions: design, plan and execute.
• Support the elaboration of analytical documents for handover to internal and external partners (for e.g., including Health authority questions /CMC modules / Manufacturing & supply operations etc.).
• Accountable to share best practices, bring strong scientific and technical expertise within the analytical project sub team, analytical scientists and across the organization.
• Work according to appropriate SOPs, GMP, GLP, QM, HSE, ISRM & Novartis Guidelines and exhibit strong team spirit and promote knowledge exchange. Embrace the Novartis Values & Behaviors, coach and mentor project team members and other associates.
• Contribute to shaping the Oligonucleotide lab further, alongside experienced experts and scientists and prepare the lab for Oligonucleotide analytics.

Minimum Requirements:

• PhD in Analytical Chemistry (or equivalent) with a minimum of 5 years of experience in pharmaceutical analytical development.
• Strong expertise in oligonucleotide analytics. Proven expertise in liquid chromatography separation techniques, including RP, IEX, and HILIC (mandatory).
• Experience in mass spectrometry, including mass confirmation, impurity quantification, and sequencing (asset). Demonstrated contribution to scientific exchange and knowledge‑sharing groups within Novartis.
• Strong scientific capability with a proven track record of guiding and mentoring colleagues. Proficiency with software and digital tools, including MS Office, LIMS, and chromatography data systems (e.g., Chromeleon).
• Solid GMP experience (mandatory). Sound understanding of regulatory and quality expectations. Strong scientific foundation with excellent communication skills, including presentations and scientific/technical writing.